MEPSGEN

MEPS-SKNVascularized Full-Thickness Skin Model

Provides perfusion flow through a vascular channel beneath full-thickness skin tissue
Supports co-culture of epidermal keratinocytes and dermal fibroblasts with an endothelialized vessel
Assesses skin barrier and inflammatory responses
Evaluates skin permeability, transdermal absorption, and vascular uptake of test compounds
Enables immune cell trafficking assays by perfusing immune cells and tracking extravasation into skin layers

MEPS-ORGALI-Enabled Advanced 3D Organoid Development

Supports long-term expansion, differentiation, and maturation of multi-layered tissues or organoids under air-liquid interface (ALI) culture conditions
Recapitulates the structural architecture and biological functions of tissue-specific organoid models
Promotes physiologically relevant epithelial differentiation and tissue maturation through ALI culture
Enables the development of advanced organoid models for lung, airway, intestinal, skin, and other epithelial tissues
Provides a controllable microenvironment for organoid growth, functional analysis, and disease modeling
Optional endothelial co-culture with perfusion enables vascularized organoid development and advanced tissue engineering applications

MEPS-TMEAdvanced 3D Tumor Microenvironment

Reconstructs a physiologically relevant tumor microenvironment (TME) within a microfluidic chip platform
Supports co-culture of tumor organoids with endothelial, stromal, and immune cells to mimic native tumor architecture and cellular interactions
Enables the generation of vascularized tumor models while preserving tumor heterogeneity and microenvironmental complexity
Facilitates retention of immune and stromal components, supporting immuno-oncology and tumor progression studies
Evaluates therapeutic responses in a physiologically relevant TME context, including drug efficacy, and immune-mediated anti-tumor activity
Provides an advanced platform for patient-derived tumor organoid (PDO) co-culture, immune-oncology research, and personalized medicine applications