PRODUCT
MEPS-BBB
3D Blood-Brain Barrier
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- Provides perfusion flow to the vascular endothelium
- Tri-cultured BBB cells
- 3D astrocyte culture with polarized end-feet processing
- Study the dynamic response of human cells to various drug administration conditions (time and dosage)
- Evaluate the permeability and mechanisms of the drug through the BBB
- Evaluate the targeting efficacy for brain cells like glia
HUMAN BLOOD-BRAIN BARRIER
- Blood flow-induced shear stress on the endothelium
- Interactions and communications of BBB cells (co-cultured)
- Astrocytic end-feet processing (AQP4, …) with healthy astrocytes (3D) vs. reactive (2D)
- 3D microenvironment (ECM: colagen4, laminin, …)
