Provides perfusion flow to vascular endothelium
Tri-cultured BBB cells
3D astrocyte culture with polarized end-feet processing
Study the dynamic response of human cells to various drug administration conditions (time and dosage)
Evaluate the permeability and mechanisms of the drug through BBB
Evaluate the targeting efficacy for brain cells like glia
Blood flow-induced shear stress on endothelium
Interactions and communications of BBB cells (co-cultured)
Astrocytic end-feet processing (AQP4,…)
3D microenvironment (ECM: colagen4, laminin, …)